My Average build for nothing special in mind would look like:
Hek (weapon augmenter) / Burston Prime (silenced and weapon augmented)
Acrid (silenced and weapon augmented)
Might take Loki for stealth or if I feel like to mix the deck, take any random frame really, but that's my most common setup.
Silenced weapons work for nearly anykind of missions and weapon augments... well, gotta love constant explosions
Nyx on the other hand can work offensively or defensively. Chaos can be life saver while on the other hand gives you time to just kill everything in the area.
Orthos... well, it's a polearm so one of the longest directional jumps, meaning for travelling. Also why go punch the enemy when we are ninjas with rocket launchers and flamethrowers, so don't really use that much other melee's, unless I want specifically focus more on melee